Cold shock domain factors activate the granulocyte-macrophage colony-stimulating factor promoter in stimulated Jurkat T cells.

@article{Diamond2001ColdSD,
  title={Cold shock domain factors activate the granulocyte-macrophage colony-stimulating factor promoter in stimulated Jurkat T cells.},
  author={Peter F. Diamond and M. Frances Shannon and Mathew A. Vadas and Leeanne S Coles},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 11},
  pages={
          7943-51
        }
}
Cold shock domain (CSD) family members have been shown to play roles in either transcriptional activation or repression of many genes in various cell types. We have previously shown that CSD proteins dbpAv and dbpB (also known as YB-1) act to repress granulocyte-macrophage colony-stimulating factor transcription in human embryonic lung (HEL) fibroblasts via binding to single-stranded DNA regions across the promoter. Here we show that the same CSD factors are involved in granulocyte-macrophage… CONTINUE READING

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