Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNF-alpha/IL-6-dependent mechanism.

@article{Selzner2002ColdID,
  title={Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: A TNF-alpha/IL-6-dependent mechanism.},
  author={Nazia Selzner and Markus Selzner and Yinghua Tian and Zakiyah Kadry and P M Clavien},
  journal={Hepatology},
  year={2002},
  volume={36 4 Pt 1},
  pages={812-8}
}
New strategies of partial liver transplantation such as cadaveric split or living related liver transplantation have been developed to overcome organ shortage. Thus, studies on the ability of small partial grafts to regenerate to normal size while maintaining adequate function have become important. Here, we evaluated the effects of cold preservation on hepatocyte proliferation and function in a novel model of partial liver transplantation in rats. Lewis rats subjected to 70% liver resection… CONTINUE READING

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