Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs.

  title={Cold-inducible RNA binding protein (CIRP) expression is modulated by alternative mRNAs.},
  author={Mohamed B Al-Fageeh and Christopher Mark Smales},
  volume={15 6},
Cold-inducible RNA binding protein (CIRP) is a mammalian protein whose expression is up-regulated in response to mild hypothermia. Although the exact function of this protein is currently unknown, it is thought to function as an RNA chaperone, facilitating mRNA translation upon the perception of cold stress. In this study we have identified and characterized the major CIRP 5'-untranslated region (5'-UTR) transcripts in mouse embryonic fibroblast NIH-3T3 cells. We show that the 5'-UTR of CIRP, a… CONTINUE READING


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