Cold but not sympathomimetics activates human brown adipose tissue in vivo.

  title={Cold but not sympathomimetics activates human brown adipose tissue in vivo.},
  author={Aaron M Cypess and Yih-Chieh S Chen and Cathy Sze and Ke Wang and J. R. English and Onyee Chan and Ashley R. Holman and Ilan Tal and Matthew R Palmer and G. M. Kolodny and C Ronald Kahn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 25},
As potential activators of brown adipose tissue (BAT), mild cold exposure and sympathomimetic drugs have been considered as treatments for obesity and diabetes, but whether they activate the same pathways is unknown. In 10 healthy human volunteers, we found that the sympathomimetic ephedrine raised blood pressure, heart rate, and energy expenditure, and increased multiple circulating metabolites, including glucose, insulin, and thyroid hormones. Cold exposure also increased blood pressure and… CONTINUE READING
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