Cold atmospheric plasma discharged in water and its potential use in cancer therapy

@article{Chen2016ColdAP,
  title={Cold atmospheric plasma discharged in water and its potential use in cancer therapy},
  author={Zhitong Chen and Xiaoqian Cheng and Li Lin and Michael Keidar},
  journal={Journal of Physics D: Applied Physics},
  year={2016},
  volume={50}
}
Cold atmospheric plasma (CAP) has emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this study we report indirect plasma treatment using CAP discharged in deionized (DI) water using three gases as carriers (argon (Ar), helium (He), and nitrogen (N2)). Plasma stimulated water was applied to the human breast cancer cell line (MDA-MB-231). MTT (3-(4, 5… 
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53 Citations
Background Citations
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Methods Citations
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53 Citations

Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

The results revealed that apoptosis efficiency was dependent on the plasma exposure time and on the levels of reactive oxygen and nitrogen species (ROS and RNS).

Cold atmospheric plasma activated deionized water using helium, argon, and nitrogen as feeding gas for cancer therapy

Cold atmospheric plasma (CAP) activated deionized (DI) water using helium (He), argon (Ar), and nitrogen (N2) as feeding gas for the cancer therapy shows that DI water treated by CAP with He feeding gas has a much stronger effect on apoptosis in precultured breast cancer cells and gastric cancer cells.

Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water.

Findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells, and elevated levels of RNS may play a more significant role than ROS in the rate of cell death.

Micro-sized cold atmospheric plasma source for brain and breast cancer treatment

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A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo

Initial observations establish the µCAP device as a potentially useful ablative therapy tool in the treatment of glioblastoma as well as boosting the applicability of the CAP method for brain tumors and reducing the gas flow rate and size of the plasma jet.

Application of a Micro-Cold Atmospheric Plasma Device (μCAP) in Vitro and Vivo for Brain Cancer Therapy

A tiny, flexible, and easy to handle CAP devices have been considered for use in medical applications and a Micro-CAP (uCAP) device employing helium gas is developed to investigate the effect of uCAP on glioblastoma cancer cells (U87) and gliOBlastoma tumors in the murine brain.

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Air cold atmospheric plasma with three different patterns for anaplastic squamous cell carcinoma treatment (VX2 cell line) showed that the air CAP with circle-pattern generated more active substances during at 60s treatment time, which resulted in a higher death rate of VX2 cells.

Combination therapy of cold atmospheric plasma (CAP) with temozolomide in the treatment of U87MG glioblastoma cells

Cold atmospheric plasma (CAP) technology can be a suitable candidate for combination therapy with existing chemotherapeutic drugs and can also be investigated in future studies for sensitizing glioblastoma cells to TMZ and other drugs available in the market.

Cold Atmospheric Plasma for Cancer Treatment: Molecular and Immunological Mechanisms

A variety of mechanisms behind the CAP cancer treatment, including apoptosis-related signaling pathways, the ROS/RNS-based “bystander effect,” ferroptosis regulation for lipid peroxidation, genetically DNA damage and cell cycle arrest, amino acid structural modification, calreticulin exposure and immune cell maturation, and necrosis are introduced.

Cold atmospheric plasma and iron oxide‐based magnetic nanoparticles for synergetic lung cancer therapy

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48 References

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