Cold atmospheric plasma discharged in water and its potential use in cancer therapy

  title={Cold atmospheric plasma discharged in water and its potential use in cancer therapy},
  author={Zhitong Chen and Xiaoqian Cheng and Li Lin and Michael Keidar},
  journal={Journal of Physics D: Applied Physics},
Cold atmospheric plasma (CAP) has emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this study we report indirect plasma treatment using CAP discharged in deionized (DI) water using three gases as carriers (argon (Ar), helium (He), and nitrogen (N2)). Plasma stimulated water was applied to the human breast cancer cell line (MDA-MB-231). MTT (3-(4, 5… 

Effects of cold atmospheric plasma generated in deionized water in cell cancer therapy

The results revealed that apoptosis efficiency was dependent on the plasma exposure time and on the levels of reactive oxygen and nitrogen species (ROS and RNS).

Cold atmospheric plasma activated deionized water using helium, argon, and nitrogen as feeding gas for cancer therapy

Cold atmospheric plasma (CAP) activated deionized (DI) water using helium (He), argon (Ar), and nitrogen (N2) as feeding gas for the cancer therapy shows that DI water treated by CAP with He feeding gas has a much stronger effect on apoptosis in precultured breast cancer cells and gastric cancer cells.

Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water.

Findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells, and elevated levels of RNS may play a more significant role than ROS in the rate of cell death.

Micro-sized cold atmospheric plasma source for brain and breast cancer treatment

It is revealed that uCAP treatment with a 20 mm length tube has a stronger effect than that of the 60 mm tube due to the synergetic effects of reactive species and free radicals.

A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo

Initial observations establish the µCAP device as a potentially useful ablative therapy tool in the treatment of glioblastoma as well as boosting the applicability of the CAP method for brain tumors and reducing the gas flow rate and size of the plasma jet.

Application of a Micro-Cold Atmospheric Plasma Device (μCAP) in Vitro and Vivo for Brain Cancer Therapy

A tiny, flexible, and easy to handle CAP devices have been considered for use in medical applications and a Micro-CAP (uCAP) device employing helium gas is developed to investigate the effect of uCAP on glioblastoma cancer cells (U87) and gliOBlastoma tumors in the murine brain.

Air cold atmospheric plasma with patterns for anaplastic squamous cell carcinoma treatment

Air cold atmospheric plasma with three different patterns for anaplastic squamous cell carcinoma treatment (VX2 cell line) showed that the air CAP with circle-pattern generated more active substances during at 60s treatment time, which resulted in a higher death rate of VX2 cells.

Combination therapy of cold atmospheric plasma (CAP) with temozolomide in the treatment of U87MG glioblastoma cells

Cold atmospheric plasma (CAP) technology can be a suitable candidate for combination therapy with existing chemotherapeutic drugs and can also be investigated in future studies for sensitizing glioblastoma cells to TMZ and other drugs available in the market.

Cold Atmospheric Plasma for Cancer Treatment: Molecular and Immunological Mechanisms

A variety of mechanisms behind the CAP cancer treatment, including apoptosis-related signaling pathways, the ROS/RNS-based “bystander effect,” ferroptosis regulation for lipid peroxidation, genetically DNA damage and cell cycle arrest, amino acid structural modification, calreticulin exposure and immune cell maturation, and necrosis are introduced.

Targeting the cancer cell cycle by cold atmospheric plasma

Cold atmospheric plasma induced a robust ~2-fold G2/M increase in two different types of cancer cells with different degrees of tumorigenicity, suggesting that tumorigenic cancer cells are more susceptible to CAP treatment.

Cold atmospheric plasma for the ablative treatment of neuroblastoma.

Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment

Using larger wells on a multi-well plate, smaller gaps between the plasma source and the media and smaller media volume enabled to obtain a stronger anti-cancer CAPs media composition without increasing the treatment time, and cysteine was the main target of effective reactive species in theCAPs media.

The Effect of Tuning Cold Plasma Composition on Glioblastoma Cell Viability

A term “plasma dosage” is defined to summarize the relationship of all the characteristics and cell viability in the plasma jet to determine a mechanism of CAP therapy on glioblastoma cells (U87) through an understanding of the composition of the plasma.

Synergistic Effect of H2O2 and NO2 in Cell Death Induced by Cold Atmospheric He Plasma

It is demonstrated that the concentration of H2O2, NO2− and NO3− can fully account for the majority of RONS produced in plasma-activated buffer, and the role of these species on the viability of normal and tumour cell lines was investigated.

Cold atmospheric plasma, a new strategy to induce senescence in melanoma cells

Differences in induction of apoptosis or senescence of tumor cells in respond to different CAP doses are observed using a new CAP device utilizing the Surface Micro Discharge (SMD) technology for plasma production in air.

Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy

The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation ofcancer treatment technologies by utilisation of another state of matter.

Cold Atmospheric Plasma: Charged Species and Their Interactions With Cells and Tissues

The selected physical properties of typical atmospheric plasma sources will be discussed; experiments will be confronted with theoretical considerations, and several biomedical aspects of CAP treatment will be surveyed.

Ablation of liver cancer cells in vitro by a plasma needle

A plasma needle using a dielectric barrier discharge reactor at atmospheric pressure with a funnel-shaped nozzle was developed. The preliminary characteristics of the plume and applications to the

Synergistic effect of gold nanoparticles and cold plasma on glioblastoma cancer therapy

It is demonstrated that there is a synergy between gold nanoparticles and cold atmospheric plasma in cancer therapy, and the concentration of AuNPs plays an important role on plasma therapy.