Cold adaptation modulates Ca2+ signaling in brown preadipocytes

  title={Cold adaptation modulates Ca2+ signaling in brown preadipocytes},
  author={Aidos Sagatovich Baumuratov and Bakhytbek B Abzhalelov and Ludmila I Kramarova and Ludmila P. Dolgacheva and Valery P. Zinchenko and Gennady E Bronnikov},
  journal={Bulletin of Experimental Biology and Medicine},
One-week cold exposure of mice led to a 2-fold increase in the density of α1-adrenoceptors in brown adipose tissue. The density of α1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via β-adrenoceptors and cAMP was transformed into the Ca2+-system induced by α1-adrenoceptors and similar to that in mature brown adipocytes.