Cold-active enzymes studied by comparative molecular dynamics simulation.

  title={Cold-active enzymes studied by comparative molecular dynamics simulation.},
  author={Vojtěch Spiwok and Petra Lipovov{\'a} and Tereza Sk{\'a}lov{\'a} and Jarmila Du{\vs}kov{\'a} and Jan Dohn{\'a}lek and Jindrich Hasek and Nicholas J. Russell and Blanka Kr{\'a}lov{\'a}},
  journal={Journal of molecular modeling},
  volume={13 4},
Enzymes from cold-adapted species are significantly more active at low temperatures, even those close to zero Celsius, but the rationale of this adaptation is complex and relatively poorly understood. It is commonly stated that there is a relationship between the flexibility of an enzyme and its catalytic activity at low temperature. This paper gives the results of a study using molecular dynamics simulations performed for five pairs of enzymes, each pair comprising a cold-active enzyme plus… CONTINUE READING


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