Cold-activated brown adipose tissue in healthy men.

@article{vanMarkenLichtenbelt2009ColdactivatedBA,
  title={Cold-activated brown adipose tissue in healthy men.},
  author={Wouter D. van Marken Lichtenbelt and Joost W. Vanhommerig and Nanda M Smulders and Jamie Drossaerts and Gerrit J. Kemerink and Nicole D Bouvy and Patrick Schrauwen and Gerrit J. J. Teule},
  journal={The New England journal of medicine},
  year={2009},
  volume={360 15},
  pages={
          1500-8
        }
}
BACKGROUND Studies in animals indicate that brown adipose tissue is important in the regulation of body weight, and it is possible that individual variation in adaptive thermogenesis can be attributed to variations in the amount or activity of brown adipose tissue. Until recently, the presence of brown adipose tissue was thought to be relevant only in small mammals and infants, with negligible physiologic relevance in adult humans. We performed a systematic examination of the presence… 
Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
Brown adipose tissue (BAT) is a site of sympathetically activated non-shivering thermognenesis during cold exposure and after spontaneous hyperphagia, thereby involving in the autonomic regulation of
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  • Biology, Medicine
    Endocrine journal
  • 2014
Brown adipose tissue (BAT) is the site of sympathetically activated adaptive thermognenesis during cold exposure and after hyperphagia, thereby controlling whole-body energy expenditure (EE) and body
Brown Adipose Tissue in Morbidly Obese Subjects
TLDR
This study shows that in an extremely large range of body compositions, BAT activity is highly correlated with BMI and BF%.
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TLDR
Suggested pathways leading to BAT activation in humans are reviewed, novel putative BAT activators in rodents into human perspective are discussed, and suggestions to increase the activity and recruitment of these thermogenic cells are discussed.
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TLDR
New possibilities to fight human obesity by stimulating energy dissipation via activation of the recently discovered brown fat depots or of the muscle CD34 progenitor cells are suggested.
Brown adipose tissue as a therapeutic target for human obesity.
  • M. Saito
  • Medicine
    Obesity research & clinical practice
  • 2013
Brown adipose tissue (BAT) is the major site of sympathetically activated adaptive thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controlling whole-body energy
Relation of Diet-Induced Thermogenesis to Brown Adipose Tissue Activity in Healthy Men.
TLDR
DIT after an oral glucose load was not associated with stimulated 18F-FDG uptake into BAT suggesting that DIT is independent from BAT activity in humans, suggesting that the relationship between human BAT activity and DIT in response to glucose intake is independent of each other.
MECHANISMS IN ENDOCRINOLOGY: Brown adipose tissue in humans: regulation and metabolic significance.
  • M. Thuzar, K. Ho
  • Biology, Medicine
    European journal of endocrinology
  • 2016
TLDR
Observations provide strong evidence that BAT plays a significant role in energy balance in humans and has the potential to be harnessed as a therapeutic target for the management of obesity.
Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans.
TLDR
CIT increased from summer to winter in a BAT-dependent manner, paralleling cold-induced changes in Tty/Tskin, indicating a role of BAT in seasonal changes in the thermogenic and thermal responses to cold exposure in humans.
Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity
TLDR
In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.
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