Colchicine poisoning: the dark side of an ancient drug
@article{Finkelstein2010ColchicinePT, title={Colchicine poisoning: the dark side of an ancient drug}, author={Yaron Finkelstein and Steven E. Aks and Janine R. Hutson and David N Juurlink and Patricia Nguyen and Gal Dubnov-Raz and Uri Pollak and Gideon Koren and Yedidia Bentur}, journal={Clinical Toxicology}, year={2010}, volume={48}, pages={407 - 414} }
Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome. Methods. We performed a systematic review by searching OVID MEDLINE between 1966 and…
379 Citations
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