Colchicine poisoning: the dark side of an ancient drug

  title={Colchicine poisoning: the dark side of an ancient drug},
  author={Yaron Finkelstein and Steven E. Aks and Janine R. Hutson and David N Juurlink and Patricia Nguyen and Gal Dubnov-Raz and Uri Pollak and Gideon Koren and Yedidia Bentur},
  journal={Clinical Toxicology},
  pages={407 - 414}
Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome. Methods. We performed a systematic review by searching OVID MEDLINE between 1966 and… 
Colchicine is a lipophilic alkaloid extract, which is isolated from Colchicum autumnale and Gloriosa superba. Colchicine has been using for centuries for the treatment of acute gout and has been
Colchicine overdose with coingestion of nonsteroidal antiinflammatory drugs.
The patient presented to the emergency department with severe nausea, vomiting, and abdominal pain following an intentional multidrug ingestion that included colchicine, indomethacin, and zopiclone, and admission to the intensive care unit was required for clinical deterioration and symptom management.
Strategy on Remedial Use of Colchicine and Its Derivatives : A Review
The present review is mainly focused on the chemistry of colchicines and its derivatives, and the upcoming demand of col chicines derivatives for curing various cancer and chronic pain.
Massive Colchicine Overdose with Recovery
Early implementation of a targeted therapeutic strategy directed at the predicted multi-organ failure which included aggressive use of a GI decontamination protocol, timely supportive measures including ventilator support and renal replacement therapy, as well as the utilization of broad-spectrum antibiotics and G-CSF for sepsis and leucopenia management, resulted in successful support and discharge of this patient off dialysis.
Lethal colchicine intoxication
A case of colchicine overdose for suicide attempt is reported, that is used for the treatment of familial Mediterranean Fever, acute gout arthritis, amyloidosis and primary biliary cirrhosis.
Colchicine for pericarditis.
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Chronic colchicine poisoning with neuromyopathy, gastric ulcers and myelosuppression in a gout patient: A case report
Colchicine overdose can mimic the clinical manifestations of several conditions, so the patient’s medication history should never be ignored.
Acute fulminant hepatic failure due to colchicine – a rare manifestation of Gloriosa superba poisoning.
A patient who ingested Gloriosa superba tubers with suicidal intent and developed acute fulminant liver failure a week after ingestion and two weeks later, he also developed alopecia, suggesting colchicine exerts a multiorgan toxicity.
Colchicine for gout
Colchicine should be considered as the optimal drug not only for relieving an acute attack of arthritis in gout, but also as the best method for preventing attacks of gouty arthritis when choosing urate-lowering therapy.


Colchicine toxicity in patients with chronic renal failure.
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Despite its hazards in chronic renal patients, colchicine is still used in gouty arthritis and in pseudogout following metastatic calcification, and became the only efficient treatment for familial Mediterranean fever and the rare Muckle-Wells syndrome.
Acute Colchicine Intoxication During Clarithromycin Administration
OBJECTIVE To report a case of colchicine intoxication occurring with institution of clarithromycin. CASE SUMMARY A 76-year-old man with familial Mediterranean fever (FMF) had received colchicine 1.5
Colchicine: 1998 update.
Colchicine poisoning: case report of two suicides.
Markedly altered colchicine kinetics in a fatal intoxication: Examination of contributing factors
This case serves as a reminder of the need for attention to co-ingested drugs, to early aggressive therapy, and if available, to consideration of immunotherapy.
Colchicine is excreted at high concentrations in human breast milk.
Colchicine overdose: the devil is in the detail.
A case series of 9 patients over the past 15 years that have presented with a colchicine overdose that resulted in death is presented and the current knowledge base about the toxicity of this drug amongst prescribers, patients, and their families is questioned.