Colchicine poisoning: the dark side of an ancient drug

@article{Finkelstein2010ColchicinePT,
  title={Colchicine poisoning: the dark side of an ancient drug},
  author={Yaron Finkelstein and Steven E. Aks and Janine R. Hutson and David N Juurlink and Patricia Nguyen and Gal Dubnov-Raz and Uri Pollak and Gideon Koren and Yedidia Bentur},
  journal={Clinical Toxicology},
  year={2010},
  volume={48},
  pages={407 - 414}
}
Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome. Methods. We performed a systematic review by searching OVID MEDLINE between 1966 and… 
FATAL INTOXICATION WITH COLCHICINE
Colchicine is a lipophilic alkaloid extract, which is isolated from Colchicum autumnale and Gloriosa superba. Colchicine has been using for centuries for the treatment of acute gout and has been
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TLDR
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