Colchicine poisoning: the dark side of an ancient drug

@article{Finkelstein2010ColchicinePT,
  title={Colchicine poisoning: the dark side of an ancient drug},
  author={Y. Finkelstein and S. Aks and J. Hutson and D. Juurlink and P. Nguyen and G. Dubnov-Raz and U. Pollak and G. Koren and Y. Bentur},
  journal={Clinical Toxicology},
  year={2010},
  volume={48},
  pages={407 - 414}
}
  • Y. Finkelstein, S. Aks, +6 authors Y. Bentur
  • Published 2010
  • Medicine
  • Clinical Toxicology
  • Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome. Methods. We performed a systematic review by searching OVID MEDLINE between 1966 and… CONTINUE READING
    284 Citations

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    This trial is to evaluate the palliative effects of colchicine on primary hepatic malignancy using the Department of Health R.O.C. approved doses and methods of administration… Expand
    ConditionsCholangiocarcinoma, Intrahepatic, Cholangiocarcinoma; With Hepatocellular Carcinoma, Hepatocellular Carcinoma Stage IIIB, (+1 more)
    InterventionDrug
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