• DOI:10.3109/15563650.2010.495348
Corpus ID: 33905426

Colchicine poisoning: the dark side of an ancient drug

@article{Finkelstein2010ColchicinePT,
  title={Colchicine poisoning: the dark side of an ancient drug},
  author={Y. Finkelstein and S. Aks and J. Hutson and D. Juurlink and P. Nguyen and G. Dubnov-Raz and U. Pollak and G. Koren and Y. Bentur},
  journal={Clinical Toxicology},
  year={2010},
  volume={48},
  pages={407 - 414}
}

Y. Finkelstein, S. Aks, +6 authors Y. Bentur

Published 2010

Medicine

Clinical Toxicology

Introduction. Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial confusion among clinicians. Although colchicine poisoning is sometimes intentional, unintentional toxicity is common and often associated with a poor outcome. Methods. We performed a systematic review by searching OVID MEDLINE between 1966 and… CONTINUE READING

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