Colchicine inhibits GABA(A) receptors independently of microtubule depolymerization.

  title={Colchicine inhibits GABA(A) receptors independently of microtubule depolymerization.},
  author={Orlando F. Bueno and Nancy J. Leidenheimer},
  volume={37 3},
Colchicine is a microtubule depolymerizing agent used extensively in the study of cytoskeleton-dependent cell functions. In studying the possible functional interaction between the GABA(A) receptor and the cytoskeleton, we found that colchicine inhibits GABA(A) receptor function by mechanisms independent of microtubule depolymerization. Human GABA(A) receptor alpha1beta2gamma2L subunits were co-expressed in Xenopus oocytes and the effects of colchicine on GABA(A) receptor function was assessed… CONTINUE READING