Colchicine inhibition of microtubule assembly via copolymer formation.

@article{Sternlicht1979ColchicineIO,
  title={Colchicine inhibition of microtubule assembly via copolymer formation.},
  author={Himan Sternlicht and Israel Ringel},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 20},
  pages={10540-50}
}
Colchicine.tubulin complex (CD) inhibits microtubule assembly. We examined this inhibition under conditions where spontaneous nucleation was suppressed and assembly was restricted to an elongation polymerization. We found that CD inhibited assembly by a mechanism which preserved the ability of microtubule ends to add tubulin. This observation is inconsistent with the end-poisoning model which recently was proposed as a general mechanism for assembly inhibition by CD. Our data are consistent… CONTINUE READING

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References

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Showing 1-3 of 3 references

Microtubules, pp

P. Dustin
1978
View 1 Excerpt

hp://w w w .jb.org/ D ow nladed from Colchicine Inhibition of Microtubule Assembly by gest on O cber 15

H. Sternhcht, I. Ringel
J. Cell Biol • 1978
View 1 Excerpt

Microtubules and Microtubule Inhibitors

L. Wilson, K. Anderson, L. Grisham, D. Chin
1975

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