Colchicine for acute and chronic coronary syndromes

@article{Imazio2020ColchicineFA,
  title={Colchicine for acute and chronic coronary syndromes},
  author={M. Imazio and A. Andreis and A. Brucato and Y. Adler and G. D. De Ferrari},
  journal={Heart},
  year={2020},
  volume={106},
  pages={1555 - 1560}
}
Colchicine is an ancient drug, traditionally used for the treatment and prevention of gouty attacks; it has become standard of treatment for pericarditis with a potential role in the treatment of coronary artery disease. Atherosclerotic plaque formation, progression, destabilisation and rupture are influenced by active proinflammatory cytokines interleukin (IL)-1β and IL-18 that are generated in the active forms by inflammasomes, which are cytosolic multiprotein oligomers of the innate immune… Expand
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Colchicine and the heart
TLDR
The aim of this review is to summarize the contemporary data supporting the efficacy and safety of colchicine in patients with CV disease. Expand
Colchicine for the Treatment of Coronary Artery Disease.
TLDR
These considerations provide a conceptual framework for the use of anti-inflammatory therapies in patients with chronic coronary syndrome or ACS and reappraise the available literature on colchicine and coronary artery disease to assess the likelihood that it might become part of the therapeutic armamentarium of this condition. Expand
Colchicine efficacy and safety for the treatment of cardiovascular diseases
TLDR
Colchicine is efficacious and safe for the treatment of cardiovascular diseases and associated with increased risk of gastrointestinal CRAEs and drug discontinuation. Expand
Anti-inflammatory Therapy for Coronary Atherosclerotic Heart Disease: Unanswered Questions Behind Existing Successes
TLDR
In this review, the successes and existing doubts of interleukin 1β antibodies, interLEukin 6 receptor antagonists, and colchicine in the anti-inflammatory treatment of coronary atherosclerotic heart disease are summarized. Expand
Meta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease.
TLDR
It is demonstrated that colchicine treatment may reduce the risk of future cardiovascular events in CAD patients and is associated with a significantly lower incidence of major adverse cardiovascular events compared with placebo or no treatment. Expand
Anti-inflammatory Therapy in Atherosclerosis: The Past and the Future
Since 1847 when Vogel, an eminent German pathologist, first observed that cholesterol was present in arterial plaques, atherosclerosis (AS) has been regarded as a cholesterol storage disease… Expand
Efficacy and safety of colchicine for the prevention of major cardiovascular and cerebrovascular events in patients with coronary artery disease: a systematic review and meta-analysis on 12 869 patients.
TLDR
The use of colchicine in patients with CAD is safe and efficacious for MACCE prevention and gastrointestinal DAEs and discontinuation may be prevented with a lower daily dose. Expand
Colchicine protects against cartilage degeneration by inhibiting MMP13 expression via PLC-γ1 phosphorylation.
  • K. Takeuchi, H. Ogawa, +8 authors H. Akiyama
  • Medicine
  • Osteoarthritis and cartilage
  • 2021
OBJECTIVE Low molecular weight compounds that reduce the expression of MMP13 at the mRNA level might serve as disease-modifying osteoarthritis (OA) drugs (DMOADs). The objective of this study was to… Expand
Efficacy and safety of colchicine for secondary prevention of coronary heart disease: a systematic review and meta-analysis
To evaluate the efficacy and safety of colchicine for secondary prevention of coronary heart disease (CHD), relevant randomized controlled trials (RCTs) were identified by searching several databases… Expand
Vaccination in Atherosclerosis
TLDR
The current vaccination strategies against atherosclerosis, supposed mechanisms of action, therapeutic potential, and the challenges that must be overcome in translating this idea into clinical practice are discussed. Expand
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The biochemical characteristics, mechanism of action and side-effects of colchicine are presented, as well as what is currently known about the promising role of col chicine in cardiovascular medicine beyond pericardial disease are examined. Expand
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