Colchicine for acute and chronic coronary syndromes
@article{Imazio2020ColchicineFA, title={Colchicine for acute and chronic coronary syndromes}, author={Massimo Imazio and A. Andreis and Antonio Luca Brucato and Yehuda Adler and Gaetano Maria De Ferrari}, journal={Heart}, year={2020}, volume={106}, pages={1555 - 1560} }
Colchicine is an ancient drug, traditionally used for the treatment and prevention of gouty attacks; it has become standard of treatment for pericarditis with a potential role in the treatment of coronary artery disease. Atherosclerotic plaque formation, progression, destabilisation and rupture are influenced by active proinflammatory cytokines interleukin (IL)-1β and IL-18 that are generated in the active forms by inflammasomes, which are cytosolic multiprotein oligomers of the innate immune…
29 Citations
Colchicine for the Treatment of Coronary Artery Disease.
- Biology, MedicineTrends in cardiovascular medicine
- 2020
Colchicine in patients with coronary heart disease: new possibilities in reduction of the residual inflammatory risk
- Medicine, BiologySiberian Medical Review
- 2021
Results of studies devoted to the use of colchicine in chronic and acute coronary syndrome are presented, including the key ones LoDoCo2 (2020) and COLCOT (2019) which provided evidence of the effect of the drug on the disease outcome.
The Role of the Inflammasome in Heart Failure
- Biology, MedicineFrontiers in Physiology
- 2021
The present review summarizes the recent advances in both basic and clinical research on the role of the inflammasome in HF and suggests that it is a critical mediator of cardiac inflammation during HF and a promising therapeutic target.
Effect of colchicine on inflammatory markers in patients with coronary artery disease: A meta-analysis of clinical trials.
- Biology, MedicineEuropean journal of pharmacology
- 2022
Colchicine efficacy and safety for the treatment of cardiovascular diseases
- Medicine, BiologyInternal and Emergency Medicine
- 2021
Colchicine is efficacious and safe for the treatment of cardiovascular diseases and associated with increased risk of gastrointestinal CRAEs and drug discontinuation.
Anti-inflammatory Therapy for Coronary Atherosclerotic Heart Disease: Unanswered Questions Behind Existing Successes
- Biology, MedicineFrontiers in Cardiovascular Medicine
- 2020
In this review, the successes and existing doubts of interleukin 1β antibodies, interLEukin 6 receptor antagonists, and colchicine in the anti-inflammatory treatment of coronary atherosclerotic heart disease are summarized.
Colchicine in Patients With Coronary Artery Disease: A Systematic Review and Meta‐Analysis of Randomized Trials
- Medicine, BiologyJournal of the American Heart Association
- 2021
Among patients with CAD, colchicine reduces the risk of myocardial infarction and stroke, but has a higher rate of gastrointestinal upset with no influence on all-cause mortality.
Meta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease.
- Biology, MedicineThe American journal of cardiology
- 2020
Anti-inflammatory Therapy in Atherosclerosis: The Past and the Future
- Medicine
- 2021
It was not until the end of 19 century that pathologists began to recognize AS as an inflammatory disease, after many years of research in the new field of vascular biology by a number of groups, notably the one by Libby.
Efficacy and safety of colchicine for the prevention of major cardiovascular and cerebrovascular events in patients with coronary artery disease: a systematic review and meta-analysis on 12 869 patients.
- Medicine, BiologyEuropean journal of preventive cardiology
- 2021
The use of colchicine in patients with CAD is safe and efficacious for MACCE prevention and gastrointestinal DAEs and discontinuation may be prevented with a lower daily dose.
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