Colchicine for acute and chronic coronary syndromes

@article{Imazio2020ColchicineFA,
  title={Colchicine for acute and chronic coronary syndromes},
  author={Massimo Imazio and A. Andreis and Antonio Luca Brucato and Yehuda Adler and Gaetano Maria De Ferrari},
  journal={Heart},
  year={2020},
  volume={106},
  pages={1555 - 1560}
}
Colchicine is an ancient drug, traditionally used for the treatment and prevention of gouty attacks; it has become standard of treatment for pericarditis with a potential role in the treatment of coronary artery disease. Atherosclerotic plaque formation, progression, destabilisation and rupture are influenced by active proinflammatory cytokines interleukin (IL)-1β and IL-18 that are generated in the active forms by inflammasomes, which are cytosolic multiprotein oligomers of the innate immune… 
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Among patients with CAD, colchicine reduces the risk of myocardial infarction and stroke, but has a higher rate of gastrointestinal upset with no influence on all-cause mortality.
Meta-analysis Evaluating the Utility of Colchicine in Secondary Prevention of Coronary Artery Disease.
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It was not until the end of 19 century that pathologists began to recognize AS as an inflammatory disease, after many years of research in the new field of vascular biology by a number of groups, notably the one by Libby.
Efficacy and safety of colchicine for the prevention of major cardiovascular and cerebrovascular events in patients with coronary artery disease: a systematic review and meta-analysis on 12 869 patients.
TLDR
The use of colchicine in patients with CAD is safe and efficacious for MACCE prevention and gastrointestinal DAEs and discontinuation may be prevented with a lower daily dose.
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