Colchicine for acute and chronic coronary syndromes

@article{Imazio2020ColchicineFA,
  title={Colchicine for acute and chronic coronary syndromes},
  author={M. Imazio and A. Andreis and A. Brucato and Y. Adler and G. D. De Ferrari},
  journal={Heart},
  year={2020},
  volume={106},
  pages={1555 - 1560}
}
Colchicine is an ancient drug, traditionally used for the treatment and prevention of gouty attacks; it has become standard of treatment for pericarditis with a potential role in the treatment of coronary artery disease. Atherosclerotic plaque formation, progression, destabilisation and rupture are influenced by active proinflammatory cytokines interleukin (IL)-1β and IL-18 that are generated in the active forms by inflammasomes, which are cytosolic multiprotein oligomers of the innate immune… Expand
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The biochemical characteristics, mechanism of action and side-effects of colchicine are presented, as well as what is currently known about the promising role of col chicine in cardiovascular medicine beyond pericardial disease are examined. Expand
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Assessment of the local cardiac production of inflammatory cytokines in patients with acute coronary syndromes (ACS), stable coronary artery disease and in controls determined whether acute administration of colchicine inhibits their production, and short-term colchichine administration rapidly and significantly reduces levels of these cytokines. Expand
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