Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production

  title={Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production},
  author={S. Lee and S. Namkoong and K. Ha and Woo-Dong Nam and Young -uen Kwon and H. Lee and Eun-Young Yoon and Dong-Jo Chang and S. Kim and Y. Kim},
  journal={Experimental & Molecular Medicine},
  • S. Lee, S. Namkoong, +7 authors Y. Kim
  • Published 2007
  • Biology, Medicine
  • Experimental & Molecular Medicine
  • Colchicine has been shown to regulate the expression of inflammatory gene, but this compound possesses much weaker anti-inflammatory activity. In this study, we synthesized a new colchicine derivative CT20126 and examined its immunomodulatory property. CT20126 was found to have immunosuppressive effects by inhibiting lymphocyte proliferation without cytotoxicity and effectively inhibit the transcriptional expression of the inflammatory genes, iNOS, TNF-α, and IL-1β, in macrophages stimulated by… CONTINUE READING
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