Colchicine blocks the effects of secretin on bile duct cell tubulovesicles and plasma membrane geometry and impairs ductular HCO3- secretion in the pig.

@article{Veel1990ColchicineBT,
  title={Colchicine blocks the effects of secretin on bile duct cell tubulovesicles and plasma membrane geometry and impairs ductular HCO3- secretion in the pig.},
  author={T Veel and Trond Buanes and Thomas Grotmol and E Engeland and Morten G Raeder},
  journal={Acta physiologica Scandinavica},
  year={1990},
  volume={139 4},
  pages={603-7}
}
Secretin causes the bile duct cells to secrete HCO3-. To examine whether the transformation of duct cell ultrastructure that follows secretin stimulation depends on microtubules and is important for ductular HCO3- secretion, we examined the effect of colchicine on ductular HCO3- secretion and on the morphology of cells lining bile ductules of anaesthetized… CONTINUE READING