Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils.

@article{Cronstein1995ColchicineAT,
  title={Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils.},
  author={Bruce Cronstein and Yair Molad and Joan Reibman and E Balakhane and Richard I. Levin and Gerald Weissmann},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 2},
  pages={
          994-1002
        }
}
Since colchicine-sensitive microtubules regulate the expression and topography of surface glycoproteins on a variety of cells, we sought evidence that colchicine interferes with neutrophil-endothelial interactions by altering the number and/or distribution of selectins on endothelial cells and neutrophils. Extremely low, prophylactic, concentrations of colchicine (IC50 = 3 nM) eliminated the E-selectin-mediated increment in endothelial adhesiveness for neutrophils in response to IL-1 (P < 0.001… CONTINUE READING

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