Coitus-induced orgasm stimulates prolactin secretion in healthy subjects

  title={Coitus-induced orgasm stimulates prolactin secretion in healthy subjects},
  author={Michael S. Exton and Tillmann H. C. Kr{\"u}ger and M Koch and Erika Paulson and Wolfram Knapp and U. Hartmann and Manfred Schedlowski},
Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject
Data from this multi-orgasmic subject support the hypothesized role of plasma prolactin in contributing to sexual-satiation mechanisms and suggest that prolactIn may form a feedback regulator of the refractory period following orgasm.
Specificity of the neuroendocrine response to orgasm during sexual arousal in men.
The results reinforce a role for prolactin either as a neuroendocrine reproductive reflex or as a feedback mechanism modulating dopaminergic systems in the central nervous system that are responsible for appetitive behavior.
Effects of acute prolactin manipulation on sexual drive and function in males.
The data demonstrate that acute changes in prolactin plasma levels may be one factor modulating sexual drive and function, and may offer a new pharmacological approach for the treatment of sexual disorders.
Prolactin secretory rhythm in women: immediate and long-term alterations after sexual contact.
A long-term change in the PRL secretory rhythm after sexual intercourse with orgasm in females is demonstrated, suggesting memory effects, and it is hypothesized that the additionally secreted PRL could be beneficial for decidualization and implantation.
Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans
A brief overview of the physiology of dopamine and prolactin in regulating sexual behavior is provided and recent experimental and clinical evidence for a postulated feedback mechanism for Prolactin and its implications for orgasmic disorders are discussed.
Effects of Sexual Arousal on Lymphocyte Subset Circulation and Cytokine Production in Man
Findings demonstrate that components of the innate immune system are activated by sexual arousal and orgasm, and this study investigated the effects of masturbation-induced orgasm on lymphocyte circulation and cytokine production in healthy young males.
No evidence for prolactin’s involvement in the post-ejaculatory refractory period
In many species, ejaculation is followed by a state of decreased sexual activity, the post-ejaculatory refractory period. Several lines of evidence have suggested prolactin, a pituitary hormone


Cardiovascular and endocrine alterations after masturbation-induced orgasm in women.
Sexual arousal and orgasm produce a distinct pattern of neuroendocrine alterations in women, primarily inducing a long-lasting elevation in plasma prolactin concentrations, suggesting that Prolactin is an endocrine marker of sexual aroused and orgasm.
Effects of chronic hyperprolactinemia on sexual arousal and erectile function in male rats.
The pituitary-grafted animals showed a significant reduction in latency to the first erection with each successive test, suggesting a delayed recovery from increased supraspinal inhibitory input.
Prolactin release after mating and genitosensory stimulation in females.
The natural mating condition reveals the contributions of the short-term and long-term mnemonic devices, establishing the existence of a graded to all-or-nothing transition that is required for the occurrence of PSP.
Suppressive effects of chronic hyperprolactinemia on penile erection and yawning following administration of apomorphine to pituitary-transplanted rats.
The results indicated that the pituitary transplantation with chronic excess of PRL and castration with T deficiency caused roughly comparable degrees of suppression of penile erectile activity through mechanisms presumably independent from one another in the rat.