Coinhibitory receptors and CD8 T cell exhaustion in chronic infections.

Abstract

PURPOSE OF REVIEW To describe the recent data on the role of coinhibitory receptors, such as PD-1, Tim-3, CD160, as mediators of the 'exhaustion' of virus-specific CD8 T cells in chronic infections and particularly in HIV. RECENT FINDINGS Exhaustion of chronic virus-specific CD8 T cells is a dynamic process characterized by altered differentiation… (More)
DOI: 10.1097/COH.0000000000000088

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