Coinhibitory Pathways in Immunotherapy for Cancer.

  title={Coinhibitory Pathways in Immunotherapy for Cancer.},
  author={Susanne H Baumeister and Gordon J Freeman and Glenn Dranoff and Arlene H Sharpe},
  journal={Annual review of immunology},
The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is immunosuppressive. Immune responses are regulated by a number of immunological checkpoints that promote protective immunity and maintain tolerance. T cell coinhibitory pathways restrict the strength and duration of immune responses, thereby limiting immune-mediated tissue damage, controlling resolution of inflammation, and… CONTINUE READING
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