Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria.

@article{McQuillan2011CoincidentPA,
  title={Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria.},
  author={James McQuillan and Andrew J Mitchell and Yuen Fern Ho and Valery Combes and Helen J. Ball and Jacob Golenser and Georges Emile Raymond Grau and Nicholas Henry Hunt},
  journal={International journal for parasitology},
  year={2011},
  volume={41 2},
  pages={155-63}
}
Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. Using a well defined murine model, we observed the effect on disease outcome of temporarily reducing parasite burden by anti-malarial drug treatment. The anti-malarial treatment regime chosen decreased parasitaemia but did not cure the mice, allowing recrudescence of parasites. These mice were protected against CM, despite their parasitaemia having increased, following treatment cessation, to levels surpassing… CONTINUE READING
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