Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.

@article{Kutzler2005CoimmunizationWA,
  title={Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.},
  author={Michele A. Kutzler and Tara M. Robinson and Michael Chattergoon and Daniel K. Choo and Andrew Y. Choo and Philip Y Choe and Mathura P. Ramanathan and Rose M Parkinson and Sagar B Kudchodkar and Yutaka Tamura and Maninder Sidhu and Vidia Roopchand and Jung-whan Kim and George N Pavlakis and Barbara K Felber and Thomas A Waldmann and Jean D. Boyer and David B. Weiner},
  journal={Journal of immunology},
  year={2005},
  volume={175 1},
  pages={
          112-23
        }
}
DNA vaccines are a promising technology for the induction of Ag-specific immune responses, and much recent attention has gone into improving their immune potency. In this study we test the feasibility of delivering a plasmid encoding IL-15 as a DNA vaccine adjuvant for the induction of improved Ag-specific CD8(+) T cellular immune responses. Because native IL-15 is poorly expressed, we used PCR-based strategies to develop an optimized construct that expresses 80-fold higher than the native IL… CONTINUE READING

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