Coilin is essential for Cajal body organization in Drosophila melanogaster.

  title={Coilin is essential for Cajal body organization in Drosophila melanogaster.},
  author={Ji-Long Liu and Zheng'an Wu and Zehra F. Nizami and Svetlana Deryusheva and T. K. Rajendra and Kelly J. Beumer and Hongjuan Gao and A Gregory Matera and Dana Carroll and Joseph G Gall},
  journal={Molecular biology of the cell},
  volume={20 6},
Cajal bodies (CBs) are nuclear organelles that occur in a variety of organisms, including vertebrates, insects, and plants. They are most often identified with antibodies against the marker protein coilin. Because the amino acid sequence of coilin is not strongly conserved evolutionarily, coilin orthologues have been difficult to recognize by homology search. Here, we report the identification of Drosophila melanogaster coilin and describe its distribution in tissues of the fly. Surprisingly… CONTINUE READING