Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

Abstract

Cohesins mediate sister chromatid cohesion, which is essential for chromosome segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene expression and enhancer-promoter interactions. These noncanonical functions remained unexplained because knowledge of cohesin-binding sites and functional interactors in metazoans was lacking… (More)
DOI: 10.1016/j.cell.2008.01.011

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