Cohesins Bind to Preferential Sites along Yeast Chromosome III, with Differential Regulation along Arms versus the Centric Region

@article{Blat1999CohesinsBT,
  title={Cohesins Bind to Preferential Sites along Yeast Chromosome III, with Differential Regulation along Arms versus the Centric Region},
  author={Yuval Blat and Nancy Kleckner},
  journal={Cell},
  year={1999},
  volume={98},
  pages={249-259}
}
Sister chromatid cohesion is mediated by evolutionary conserved chromosomal proteins, termed "cohesins." Using an extension of chromatin immunoprecipitation, we have analyzed the distribution of cohesins Mcd1/ Sccl and Smc1 along yeast chromosome III. Both proteins occur preferentially at the same approximately 23 positions. Sites in a approximately 50 kb region around the centromere give especially intense signals. Prominent centric region binding appears to emerge from a more even… CONTINUE READING
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Rec 8 p , a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad 21 p family ,

  • J. H. J. makers, J. Kohli
  • 1999

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