Cohesinopathy mutations disrupt the subnuclear organization of chromatin

@inproceedings{Gard2009CohesinopathyMD,
  title={Cohesinopathy mutations disrupt the subnuclear organization of chromatin},
  author={Scarlett Gard and William H. Light and Bo Xiong and Tania Bose and Adrian J. McNairn and Bethany R. Harris and Brian E Fleharty and Chris Seidel and Jason H Brickner and Jennifer L Gerton},
  booktitle={The Journal of cell biology},
  year={2009}
}
In Saccharomyces cerevisiae, chromatin is spatially organized within the nucleus with centromeres clustering near the spindle pole body, telomeres clustering into foci at the nuclear periphery, ribosomal DNA repeats localizing within a single nucleolus, and transfer RNA (tRNA) genes present in an adjacent cluster. [corrected] Furthermore, certain genes relocalize from the nuclear interior to the periphery upon transcriptional activation. The molecular mechanisms responsible for the organization… CONTINUE READING

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