Cohesin ties up the genome.

@article{Carretero2010CohesinTU,
  title={Cohesin ties up the genome.},
  author={Mar{\'i}a Emilia Carretero and Silvia Remeseiro and Ana Losada},
  journal={Current opinion in cell biology},
  year={2010},
  volume={22 6},
  pages={781-7}
}
Cohesin was originally identified as a mediator of sister chromatid cohesion both in mitosis and meiosis. Emerging evidences suggest that it also participates in the organization of interphase chromatin. The ring-shaped complex regulates gene expression by constraining chromatin topology in concert with factors such as the insulator CTCF, at least in… CONTINUE READING