Cohesin relocation from sites of chromosomal loading to places of convergent transcription

@article{Lengronne2004CohesinRF,
  title={Cohesin relocation from sites of chromosomal loading to places of convergent transcription},
  author={Armelle Lengronne and Yuki Katou and Saori Mori and Shihori Yokobayashi and Gavin Kelly and Takehiko Itoh and Yoshinori Watanabe and Katsuhiko Shirahige and Frank Uhlmann},
  journal={Nature},
  year={2004},
  volume={430},
  pages={573-578}
}
Sister chromatids, the products of eukaryotic DNA replication, are held together by the chromosomal cohesin complex after their synthesis. This allows the spindle in mitosis to recognize pairs of replication products for segregation into opposite directions1,2,3,4,5,6. Cohesin forms large protein rings that may bind DNA strands by encircling them7, but the characterization of cohesin binding to chromosomes in vivo has remained vague. We have performed high resolution analysis of cohesin… CONTINUE READING
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