Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

@article{Faure2012CohesinRT,
  title={Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.},
  author={Andre J. Faure and Dominic Schmidt and Stephen Watt and Petra C. Schwalie and Michael D. Wilson and Huiling Xu and R G Ramsay and Duncan T. Odom and Paul Flicek},
  journal={Genome research},
  year={2012},
  volume={22 11},
  pages={2163-75}
}
The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master regulators at tissue-specific loci. The regulation of transcription involves the concerted action of multiple transcription factors (TFs) and cohesin's role in this context of combinatorial TF binding remains unexplored. To investigate cohesin-non-CTCF (CNC) binding events in vivo we mapped cohesin and CTCF, as well as a collection of tissue-specific and ubiquitous… CONTINUE READING
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