Cohesin-dependent regulation of Runx genes.

@article{Horsfield2007CohesindependentRO,
  title={Cohesin-dependent regulation of Runx genes.},
  author={Julia A Horsfield and Sasha H. Anagnostou and Jimmy Kuang-Hsien Hu and Kitty Hsiao Yu Cho and Robert Geisler and Graham J. Lieschke and Kathryn E. Crosier and Philip S. Crosier},
  journal={Development},
  year={2007},
  volume={134 14},
  pages={
          2639-49
        }
}
Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We conducted a forward genetic screen in zebrafish for positive regulators of runx1 that yielded the cohesin subunit rad21. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development. Failure to develop… CONTINUE READING
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