Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.

@article{Zuin2014CohesinAC,
  title={Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.},
  author={Jessica Zuin and Jesse R. Dixon and Michael I. J. A. van der Reijden and Zhen Ye and Petros Kolovos and Rutger W. W. Brouwer and Mari{\"e}tte P C van de Corput and Harmen J G van de Werken and Tobias A. Knoch and Wilfred F J van Ijcken and Frank G. Grosveld and Bing Ren and Kerstin S Wendt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 3},
  pages={996-1001}
}
Recent studies of genome-wide chromatin interactions have revealed that the human genome is partitioned into many self-associating topological domains. The boundary sequences between domains are enriched for binding sites of CTCC-binding factor (CTCF) and the cohesin complex, implicating these two factors in the establishment or maintenance of topological domains. To determine the role of cohesin and CTCF in higher-order chromatin architecture in human cells, we depleted the cohesin complex or… CONTINUE READING
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A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature 476(7361):467–471

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