Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.

  title={Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells.},
  author={Jessica Zuin and Jesse R. Dixon and Michael I. J. A. van der Reijden and Zhen Ye and Petros Kolovos and Rutger W. W. Brouwer and Mari{\"e}tte P C van de Corput and Harmen J G van de Werken and Tobias A. Knoch and Wilfred F J van Ijcken and Frank G. Grosveld and Bing Ren and Kerstin S Wendt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 3},
Recent studies of genome-wide chromatin interactions have revealed that the human genome is partitioned into many self-associating topological domains. The boundary sequences between domains are enriched for binding sites of CTCC-binding factor (CTCF) and the cohesin complex, implicating these two factors in the establishment or maintenance of topological domains. To determine the role of cohesin and CTCF in higher-order chromatin architecture in human cells, we depleted the cohesin complex or… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 12 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 232 extracted citations

Cohesin and Condensin

  • Kyoko Yokomori Katsuhiko
  • Methods in Molecular Biology
  • 2017
Highly Influenced
20 Excerpts


Publications referenced by this paper.
Showing 1-10 of 28 references

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature 476(7361):467–471

  • VC Seitan
  • Zuin et al. PNAS | January
  • 2011
2 Excerpts

Similar Papers

Loading similar papers…