Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides.

@article{Wenschuh2000CoherentMS,
  title={Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides.},
  author={Holger Wenschuh and Rudolf Volkmer-Engert and Manfred Einsiedler Klaus Schmidt and Matthias Schulz and Jens Schneider-Mergener and Ulrich Reineke},
  journal={Biopolymers},
  year={2000},
  volume={55 3},
  pages={188-206}
}
Since its invention the SPOT-synthesis methodology has become one of the most efficient strategies for the miniaturized assembly of large numbers of peptides. The combination of a facile synthetic method with high throughput solid- and solution-phase screening assays qualifies the SPOT-technique as a valuable tool in biomedical research. Recent developments such as the introduction of novel polymeric surfaces, new linker and cleavage strategies as well as automated robot systems extended the… CONTINUE READING