Coherent angular motion in the establishment of multicellular architecture of glandular tissues.

@article{Tanner2012CoherentAM,
  title={Coherent angular motion in the establishment of multicellular architecture of glandular tissues.},
  author={Kandice Tanner and Hidetoshi Mori and Rana Mroue and Alexandre Bruni-Cardoso and Mina J. Bissell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 6},
  pages={1973-8}
}
Glandular tissues form ducts (tubes) and acini (spheres) in multicellular organisms. This process is best demonstrated in the organization of the ductal tree of the mammary gland and in 3D models of morphogenesis in culture. Here, we asked a fundamental question: How do single adult epithelial cells generate polarized acini when placed in a surrogate basement membrane 3D gel? Using human breast epithelial cells from either reduction mammoplasty or nonmalignant breast cell lines, we observed a… CONTINUE READING