Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions

@inproceedings{Hallwirth2015CoherenceAD,
  title={Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions},
  author={Claus V. Hallwirth and Gagan Garg and Timothy J. Peters and Belinda A Kramer and Nirav Malani and Jessica Hyman and Xiaoan Ruan and Samantha L. Ginn and Nicola A. Hetherington and Lavanya Veeravalli and Atif Shahab and Shoba Ranganathan and Chia-Lin Wei and Christopher Liddle and Adrian J. Thrasher and Frederic D. Bushman and Michael J. Buckley and Ian E. Alexander},
  booktitle={Molecular therapy. Methods & clinical development},
  year={2015}
}
Unequivocal demonstration of the therapeutic utility of γ-retroviral vectors for gene therapy applications targeting the hematopoietic system was accompanied by instances of insertional mutagenesis. These events stimulated the ongoing development of putatively safer integrating vector systems and analysis methods to characterize and compare integration site (IS) biosafety profiles. Continuing advances in next-generation sequencing technologies are driving the generation of ever-more complex IS… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…