Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction.

@article{Jokinen2013CognitiveSI,
  title={Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction.},
  author={Pekka Jokinen and Mira Karrasch and Anna Br{\"u}ck and Jarkko Johansson and J{\"o}rgen Bergman and Juha O. Rinne},
  journal={Journal of the neurological sciences},
  year={2013},
  volume={329 1-2},
  pages={23-8}
}
BACKGROUND Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex. METHODS The authors evaluated the relationship between frontostriatal dopaminergic function and cognitive performance, especially cognitive processing speed by performing [(18)F]fluorodopa PET and computerized tests of automatic and controlled cognitive… CONTINUE READING
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