Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil

@article{Peretti2004CognitiveSL,
  title={Cognitive skill learning in healthy older adults after 2 months of double-blind treatment with piribedil},
  author={Charles Siegfried Peretti and Fabien Gierski and Sophie Harrois},
  journal={Psychopharmacology},
  year={2004},
  volume={176},
  pages={176-182}
}
RationaleCognitive skill learning, as assessed by repeated testing on the Tower of Toronto (TT) task, has been found to be impaired in normal aging. There is evidence that this impairment might be accounted for by the well-documented, age-dependent decline of dopamine D2-like receptor availability.ObjectivesThis study was an investigation of whether the D2/D3 dopaminergic agonist piribedil improves cognitive skill learning in older adults.MethodsHealthy elderly volunteers were assessed using… 
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Piribedil was considered in the last Movement Disorder Society Evidence-Based Medicine review as “efficacious” and “clinically useful” for the symptomatic treatment of PD, either as monotherapy or in conjunction with levodopa, in non-fluctuating early PD patients.
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Improved neuropsychological assessment and characterization of other domains, such as executive function and attention, may assist in better identifying the pathophysiology of deficits in these areas, perhaps in combination with new technologies such as functional imaging.
Visuomotor binding in older adults
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