Cognitive reserve and cortical atrophy in multiple sclerosis: a longitudinal study.

@article{Amato2013CognitiveRA,
  title={Cognitive reserve and cortical atrophy in multiple sclerosis: a longitudinal study.},
  author={Maria Pia Amato and Lorenzo Razzolini and Benedetta Goretti and Maria Laura Stromillo and Francesca Rossi and Antonio Di Giorgio and Bahia Hakiki and Marta Giannini and Luisa Past{\`o} and Emilio Portaccio and Nicola De Stefano},
  journal={Neurology},
  year={2013},
  volume={80 19},
  pages={
          1728-33
        }
}
OBJECTIVE To test the cognitive reserve (CR) hypothesis in the model of multiple sclerosis (MS) by assessing the interactions among CR, brain atrophy, and cognitive efficiency in patients with relapsing-remitting MS. METHODS A Cognitive Reserve Index was calculated including education, premorbid leisure activities, and IQ. Brain atrophy was assessed through magnetic resonance quantitative parameters of normalized total brain volume and normalized cortical volume. Cognitive function was… CONTINUE READING
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