Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study

@article{Bottino2005CognitiveRC,
  title={Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study},
  author={C{\'a}ssio Machado Campos Bottino and Isabel A. M. Carvalho and Ana Maria M A Alvarez and Renata Thomas {\'A}vila and Patr{\'i}cia Ribeiro Zukauskas and Sonia E Zevallos Bustamante and Fl{\'a}via C Andrade and S{\'e}rgio Ricardo Hototian and Fabiana Saffi and C{\^a}ndida Helena P. Camargo},
  journal={Clinical Rehabilitation},
  year={2005},
  volume={19},
  pages={861 - 869}
}
Objective: To study the efficacy of cognitive rehabilitation combined with acetylcholinesterase inhibitor (AChE-I) treatment in patients with mild Alzheimer's disease and their relatives. Method: Thirteen patients with mild Alzheimer's disease treated with rivastigmine 6-12 mg/day for more than two months started cognitive rehabilitation training. Before and after the cognitive rehabilitation training patients were assessed through cognitive tests, activities of daily living scale… 
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TLDR
It is suggested that participation in a 6-month cognitive intervention can improve cognitive and non-cognitive functions in aMCI subjects and in contrast, AD patients showed no significant benefit from intervention.
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Cognitive intervention therapy as treatment for behaviour disorders in Alzheimer disease: evidence on efficacy and neurobiological correlations.
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TLDR
The goal is to stimulate discussion among researchers and clinicians alike on how treatment effects may be mediated by engagement in treatment, and what can be done to enhance patient adherence for cognitive rehabilitation therapies in order to obtain greater cognitive and functional benefits from the treatment itself.
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