Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study.

@article{Hershey2004CognitivepharmacologicFM,
  title={Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study.},
  author={Tamara Hershey and Kevin J. Black and Johanna M. Hartlein and Deanna M. Barch and Todd S. Braver and Juanita L. Carl and Joel S. Perlmutter},
  journal={Biological psychiatry},
  year={2004},
  volume={55 9},
  pages={916-25}
}
BACKGROUND Dopamine agonists and antagonists can reduce abnormal movements and vocalizations (tics) in Tourette syndrome (TS); however, dopamine-responsive abnormal function in specific brain regions has not been directly demonstrated in TS. We sought to identify dopamine-modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging (fMRI), a working memory (WM) task, and infusion of the dopamine prodrug levodopa (while blocking dopamine production… CONTINUE READING

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We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
Frontal lobe gyrusAnatomic structure is physical part ofCerebral cortex
In TS subjects , the task induced excessive brain activity in parietal cortex , medial frontal gyrus , and thalamus .
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
We sought to identify dopamine - modulated brain regions that function abnormally in TS by combining functional magnetic resonance imaging ( fMRI ) , a working memory ( WM ) task , and infusion of the dopamine prodrug levodopa ( while blocking dopamine production outside the brain )
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