Cognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits

@article{Parrott1998CognitivePI,
  title={Cognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits},
  author={Andrew C. Parrott and A. J. Lees and Nathan Garnham and M. Jones and Keith A Wesnes},
  journal={Journal of Psychopharmacology},
  year={1998},
  volume={12},
  pages={79 - 83}
}
Cognitive task performance was assessed in three groups of young people: 10 regular users of 3,4- methylenedioxymethamphetamine (MDMA) who had taken 'ecstasy' 10 times or more; 10 novice MDMA users who had taken 'ecstasy' one to nine times; and 10 control subjects who had never taken MDMA. A computerized battery of cognitive tasks (Cognitive Drug Research system) was undertaken on a day when subjects were drug free. Performance on the response speed and vigilance measures (simple reaction time… 

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References

SHOWING 1-10 OF 31 REFERENCES
Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function?
TLDR
Concern is raised about possible detrimental effects of MDMA use on neuropsychological function for future systematic study and important issues regarding the effects of 5-HT deficits on cognitive function and mood regulation are highlighted.
Mood and cognitive effects of +/-3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'): week-end 'high' followed by mid-week low.
TLDR
Weekend use of MDMA may lead to depressed mood mid-week, and possible mechanisms underlying the findings are discussed in terms of temporary depletion of serotonin, serotonergic neurotoxity and psychological aspects of mood change.
Ecstasy (MDMA) in Recreational Users: Self‐Reported Psychological and Physiological Effects
Twenty recreational drug users were asked to describe the psychological and physiological effects they experienced under MDMA (3,4‐methylenedioxymethamphetamine). The subjects comprised 11 males and
Effects of MDMA on Complex Brain Function in Laboratory Animals
Subjective effects of 3,4-methylenedioxymethamphetamine in recreational users.
  • S. Peroutka, H. Newman, H. Harris
  • Psychology
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1988
TLDR
These observations should be considered preliminary, they represent the first documentation of the subjective effects of MDMA in recreational users and confirm previous reports obtained from patients treated with this drug.
Ecstasy (MDMA), amphetamine, and LSD: comparative mood profiles in recreational polydrug users
Twenty‐one recreational polydrug users (age range: 17–34 years), were recruited into the study using the ‘snowball’ technique (Solowij et al., 1992). All had used MDMA
Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans
TLDR
Differences in personality support the view that 5-HT systems are involved in modulating impulsive and aggressive personality traits and suggest that5-HT neurotoxicity may be a potential complication of MDMA use.
Recreational MDMA use in Sydney: a profile of 'Ecstacy' users and their experiences with the drug.
TLDR
The research revealed that Ecstasy is primarily used by infrequent recreational drug users for 'fun' at dance parties and social gatherings and tolerance was reported to develop to the positive effects of Ecstasy, while negative effects increased with use.
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans.
TLDR
Improved recognition of MDMA-related syndromes is hoped to provide insight into the function of serotonin in the human brain, in health as well as disease.
...
1
2
3
4
...