Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.

Abstract

The α7 nicotinic acetylcholine receptor (nAChR) is a recognized drug target for dementias of aging and certain developmental disorders. Two selective and potent α7-nAChR agonists, winnowed from a list of 43 compounds characterized in a companion article (DOI: 10.1021/acschemneuro.5b00058), 5-((quinuclid-3-yl)-1H-1,2,3-triazol-4-yl)-1H-indole (IND8) and 3-(4… (More)
DOI: 10.1021/acschemneuro.5b00059

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Cite this paper

@article{Arunrungvichian2015CognitiveII, title={Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors.}, author={Kuntarat Arunrungvichian and Chantana Boonyarat and Valery V. Fokin and Palmer Taylor and Opa Vajragupta}, journal={ACS chemical neuroscience}, year={2015}, volume={6 8}, pages={1331-40} }