Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain.

@article{PaisVieira2009CognitiveIO,
  title={Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain.},
  author={Miguel Pais-Vieira and Maria Manuela Mendes-Pinto and Deolinda Lima and Vasco Galhardo},
  journal={Neuroscience},
  year={2009},
  volume={161 3},
  pages={671-9}
}
Forced choice between alternative options of unpredictable outcome is a complex task that requires continual update of the value associated with each option. Prefrontal areas such as the orbitofrontal cortex (OFC) have been shown to play a major role in performance on ambiguous decision-making tasks with substantial risk component, broadly named as "gambling tasks." We have recently demonstrated that rats display complex decision-making behavior in a rodent gambling task based on serial choices… CONTINUE READING
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