Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis.

  title={Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis.},
  author={Lars A B{\"a}ckman and Sari Jones and A W Berger and Erika J. Laukka and Brent J. Small},
  volume={19 4},
To determine the size of the impairment across different cognitive domains in preclinical Alzheimer's disease (AD), a meta-analysis based on 47 studies involving 9,097 controls and 1,207 preclinical AD cases was conducted. There were marked preclinical deficits in global cognitive ability, episodic memory, perceptual speed, and executive functioning; somewhat smaller deficits in verbal ability, visuospatial skill, and attention; and no preclinical impairment in primary memory. Younger age (< 75… CONTINUE READING
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