Cognitive impairment in first-episode drug-naïve patients with schizophrenia: Relationships with serum concentrations of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor

@article{Xiao2017CognitiveII,
  title={Cognitive impairment in first-episode drug-na{\"i}ve patients with schizophrenia: Relationships with serum concentrations of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor},
  author={Wenhuan Xiao and Fei Ye and Chunlai Liu and Xiaowei Tang and Xiaobin Zhang},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2017},
  volume={76},
  pages={163-168}
}
OBJECTIVES Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia. METHODS The BDNF and GDNF levels of 58 FEDN patients and 55 age… CONTINUE READING