Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

@article{Frhlich2016CognitiveIB,
  title={Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication},
  author={Esther E Fr{\"o}hlich and Aitak Farzi and Raphaela Mayerhofer and Florian Reichmann and Angela Ja{\vc}an and Bernhard Wagner and Erwin Zinser and Natalie Bordag and Christoph Magnes and Eleonore Fr{\"o}hlich and Karl Kashofer and Gregor Gorkiewicz and Peter Holzer},
  journal={Brain, Behavior, and Immunity},
  year={2016},
  volume={56},
  pages={140-155}
}
Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health. Germ-free mice and antibiotic-induced gut dysbiosis are two approaches to establish causality in gut microbiota-brain relationships. However, both models have limitations, as germ-free mice display alterations in blood-brain barrier and brain ultrastructure and antibiotics may act directly on the brain. We hypothesized that the concerns related to antibiotic-induced gut dysbiosis can… CONTINUE READING
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