Cognitive impairment and Alzheimer’s disease: Links with oxidative stress and cholesterol metabolism

@article{Sekler2008CognitiveIA,
  title={Cognitive impairment and Alzheimer’s disease: Links with oxidative stress and cholesterol metabolism},
  author={Alejandra Sekler and Jose M Jim{\'e}nez and Leonel E. Rojo and Edgard Pastene and Patricio Fuentes and Andrea Slachevsky and Ricardo Benjamin Maccioni},
  journal={Neuropsychiatric Disease and Treatment},
  year={2008},
  volume={4},
  pages={715 - 722}
}
Oxidative stress has been implicated in the progression of a number of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease and amyotrophic lateral sclerosis. We carried out an in-depth study of cognitive impairment and its relationships with oxidative stress markers such as ferric-reducing ability of plasma (FRAP), plasma malondialdehyde and total antioxidative capacity (TAC), as well as cholesterol parameters, in two subsets of subjects, AD patients (n = 59) and… CONTINUE READING
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