Cognitive function in untreated hypothyroidism and hyperthyroidism

@article{Samuels2008CognitiveFI,
  title={Cognitive function in untreated hypothyroidism and hyperthyroidism},
  author={Mary Samuels},
  journal={Current Opinion in Endocrinology, Diabetes and Obesity},
  year={2008},
  volume={15},
  pages={429–433}
}
  • M. Samuels
  • Published 2008
  • Medicine
  • Current Opinion in Endocrinology, Diabetes and Obesity
Purpose of reviewThe brain is an important target organ for thyroid hormone, and alterations in mood and cognition may occur with thyroid dysfunction. Recent advances in the field of cognitive neurosciences have allowed more sensitive and focused testing of cognitive domains in patients with altered thyroid function. Recent findingsBased on recent population-based studies, there do not appear to be major deficits in cognitive functioning in overt or subclinical thyroid disease. However… Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Neuropsychiatric aspects of hypothyroidism and treatment reversibility. .
TLDR
Control studies suggest that cognitive and mood symptoms improve with treatment, though the data are equivocal and limited by diverse methodologies, and Limitations of the current literature and future directions are discussed. Expand
Is Subclinical Thyroid Dysfunction in the Elderly Associated with Depression or Cognitive Dysfunction?
TLDR
This study provides good evidence that subclinical thyroid dysfunction is not related to disorders of cognition and mood in older persons, and examines possible associations in a large community-based cohort of persons 65 years of age or older (the Birmingham Elderly Thyroid Study). Expand
Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment.
TLDR
In subjects with SHT where the serum TSH level is in the 3.5-10.0 mIU/liter range, there are no neuropsychological dysfunction, and compared with healthy controls, there is no difference in symptoms related to hypothyroidism. Expand
MEMORY IMPROVEMENT WITH TREATMENT OF HYPOTHYROIDISM
TLDR
It is suggested that specific memory retrieval deficits associated with hypothyroidism can resolve after replacement therapy with levothyroxine. Expand
Thyroid hormones, dementia, and atrophy of the medial temporal lobe.
TLDR
In this study, TSH was related neither to risk of AD nor with early MRI markers thereof, arguing against an important role of thyroid function in the development of AD. Expand
fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism.
TLDR
It is suggested that working memory (but not other memory functions) is impaired in SCH patients, mainly as far as disorders of the frontoparietal network were concerned. Expand
Verbal memory retrieval deficits associated with untreated hypothyroidism.
TLDR
Results suggest that hypothyroid-related memory deficits are not attributable to an attentional deficit but rather to specific retrieval deficits. Expand
Thyroid status, disability and cognitive function, and survival in old age.
TLDR
In the general population of the oldest old, elderly individuals with abnormally high levels of thyrotropin do not experience adverse effects and may have a prolonged life span, however, evidence for not treating elderly individuals can only come from a well-designed, randomized placebo-controlled clinical trial. Expand
Health status, mood, and cognition in experimentally induced subclinical thyrotoxicosis.
TLDR
It is suggested that thyroid hormone directly affects brain areas responsible for affect and motor function in hypothyroid subjects when subclinical thyrotoxicosis was induced in a blinded, randomized fashion. Expand
Health status, mood, and cognition in experimentally induced subclinical hypothyroidism.
TLDR
There were independent decrements in working memory, which suggests that subclinical hypothyroidism specifically impacts brain areas responsible for working memory. Expand
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