Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer’s disease

@article{Dam2007CognitiveEO,
  title={Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer’s disease},
  author={Debby Van Dam and Katrien Coen and Peter Paul De Deyn},
  journal={Psychopharmacology},
  year={2007},
  volume={197},
  pages={37-43}
}
The interest for acetylcholinesterase inhibitors in the treatment of Alzheimer’s disease has been greatly renewed owing to the discovery of a broad range of additional cholinergic and non-cholinergic effects, exploitable to maximize the efficacy of these drugs beyond merely improving intellectual functions at the symptomatic level. The age-dependent cognitive decline in the valid APP23 transgenic mouse model for Alzheimer’s disease was employed to evaluate disease-modifying efficacy of chronic… CONTINUE READING

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