Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice

Abstract

A subset of patients with Parkinson's disease acquires a debilitating dementia characterized by severe cognitive impairments (i.e. Parkinson's disease dementia; PDD). Brains from PDD patients show extensive cholinergic loss as well as dopamine (DA) depletion. We used a mutant mouse model to directly test whether combined cholinergic and DA depletion leads… (More)
DOI: 10.1242/dmm.010363

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