Cognitive effects of creatine ethyl ester supplementation

@article{Ling2009CognitiveEO,
  title={Cognitive effects of creatine ethyl ester supplementation},
  author={J. Ling and Minos Kritikos and Brian Tiplady},
  journal={Behavioural Pharmacology},
  year={2009},
  volume={20},
  pages={673-679}
}
Supplementation with creatine-based substances as a means of enhancing athletic performance has become widespread. [...] Key Method This study used a new form of creatine--creatine ethyl ester--to investigate whether supplementation would improve performance in five cognitive tasks, using a double-blind, placebo-controlled study. Creatine dosing led to an improvement over the placebo condition on several measures. Although creatine seems to facilitate cognition on some tasks, these results require replication…Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation
TLDR
Using double-blind placebo-controlled paradigm, it is demonstrated that dietary supplement of creatine reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. Expand
Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial
TLDR
A dynamic and significant role of brain energy capacity in influencing brain performance is underline in this work, with Creatine supplementation having a significant positive effect on both working memory and intelligence in 45 young adult, vegetarian subjects. Expand
Scientific basis and practical aspects of creatine supplementation for athletes.
TLDR
The predominance of research indicates that creatine supplementation represents a safe, effective, and legal method to enhance muscle size and strength responses to resistance training. Expand
Pharmacokinetics of the Dietary Supplement Creatine
TLDR
Overall, there are very limited pharmacokinetic data available for creatine, and further studies are needed to define absorption characteristics, clearance kinetics and the effect of multiple doses, and the relationship between plasma creatine and muscle creatine needs to be elucidated to optimise administration regimens. Expand
Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
TLDR
Oral creatine supplementation displayed neuroprotective effects in several animal models of neurological disease, and creatine biosynthesis has been postulated as a major effector of homocysteine concentration in the plasma, which has been identified as an independent graded risk factor for atherosclerotic disease. Expand
Creatine therapy in myophosphorylase deficiency (McArdle disease): a placebo-controlled crossover trial.
TLDR
This is the first controlled study indicating that creatine supplementation improves skeletal muscle function in McArdle disease. Expand
Creatine replacement therapy in guanidineoacetate methyltransferase deficiency, a novel inborn error of metabolism
TLDR
Long-term oral administration of creatine-monohydrate to an infant with extrapyramidal signs resulted in substantial clinical improvement, disappearance of magnetic resonance (MRI) signal abnormalities in the globus pallidus, and normalisation of slow background activity on the electroencephalogram (EEG). Expand
Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism
ABSTRACT: In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalizedExpand
Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration.
TLDR
Findings indicate that co-ingestion of alpha-lipoic acid with creatine and a small amount of sucrose can enhance muscle total creatine content as compared to the ingestion of creatine and sucrose or creatine alone. Expand
Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease
TLDR
Creatine supplementation led to increases in fat-free mass, peripheral muscle strength and endurance, health status, but not exercise capacity, and may constitute a new ergogenic treatment in COPD. Expand
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