Cognitive effects of creatine ethyl ester supplementation

  title={Cognitive effects of creatine ethyl ester supplementation},
  author={J. Ling and Minos Kritikos and Brian Tiplady},
  journal={Behavioural Pharmacology},
Supplementation with creatine-based substances as a means of enhancing athletic performance has become widespread. [] Key Method This study used a new form of creatine--creatine ethyl ester--to investigate whether supplementation would improve performance in five cognitive tasks, using a double-blind, placebo-controlled study. Creatine dosing led to an improvement over the placebo condition on several measures. Although creatine seems to facilitate cognition on some tasks, these results require replication…

ff ects of creatine supplementation on cognitive function of healthy individuals : A systematic review of randomized controlled trials

Oral creatine administration may improve short-term memory and intelligence/reasoning of healthy individuals but its effect on other cognitive domains remains unclear and suggest potential benefit for aging and stressed individuals.

Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury

Evidence exists indicating that increased brain creatine may be effective at reducing the severity of, or enhancing recovery from mild traumatic brain injury, however, only limited data in humans are available to verify this hypothesis, thus representing an exciting area for further research.

Effects of Creatine Supplementation on Brain Function and Health

The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, and outline recent advances on creatine supplementation as a neuroprotective supplement.

Does brain creatine content rely on exogenous creatine in healthy youth? A proof-of-principle study.

A 7-day creatine supplementation protocol did not elicit improvements in brain creatine content or cognitive performance in healthy youth, suggesting that this population mainly relies on brain creatine synthesis rather than exogenous creatine intake to maintain brain creatine homeostasis.

Creatine Supplementation and Brain Health

There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors or chronic, pathologic conditions.

Use of creatine in the elderly and evidence for effects on cognitive function in young and old

In older adults, concurrent creatine supplementation and resistance training increase lean body mass, enhance fatigue resistance, increase muscle strength, and improve performance of activities of daily living to a greater extent than resistance training alone.

Creatine and creatine forms intended for sports nutrition

Considering an acceptable creatine intake of 3 g per day, most of the evaluated creatine forms are unlikely to pose safety concerns, however some safety concerns regarding a supplementary intake of creatine orotate, creatine phosphate, and magnesium creatine chelate are discussed here.

Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials.

Creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (66-76 years), especially in young adults (11-31  years).



Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation

Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial

A dynamic and significant role of brain energy capacity in influencing brain performance is underline in this work, with Creatine supplementation having a significant positive effect on both working memory and intelligence in 45 young adult, vegetarian subjects.

Pharmacokinetics of the Dietary Supplement Creatine

Overall, there are very limited pharmacokinetic data available for creatine, and further studies are needed to define absorption characteristics, clearance kinetics and the effect of multiple doses, and the relationship between plasma creatine and muscle creatine needs to be elucidated to optimise administration regimens.

Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism

ABSTRACT: In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in vivo proton magnetic resonance spectroscopy disclosed a generalized

Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration.

Findings indicate that co-ingestion of alpha-lipoic acid with creatine and a small amount of sucrose can enhance muscle total creatine content as compared to the ingestion of creatine and sucrose or creatine alone.

Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease

Creatine supplementation led to increases in fat-free mass, peripheral muscle strength and endurance, health status, but not exercise capacity, and may constitute a new ergogenic treatment in COPD.

Single‐ and Multiple‐Dose Pharmacokinetics of Oral Creatine

Repeat dosing of Cr caused a reduction in clearance that could result from saturation of the skeletal muscle pool of Cr, and a model incorporating a saturable absorption and first‐order elimination process was fitted.