Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP)

@article{FeriniStrambi2003CognitiveDI,
  title={Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP)},
  author={Luigi Ferini-Strambi and Chiara Baietto and M. R. Di Gioia and Paola Castaldi and Cinzia Castronovo and Marco Zucconi and Stefano F. Cappa},
  journal={Brain Research Bulletin},
  year={2003},
  volume={61},
  pages={87-92}
}
Obstructive sleep apnea: neurocognitive and behavioral functions before and after treatment.
TLDR
CPAP treatment has significant effects on different cognitive domains in patients with OSAS, especially working memory, long-term verbal memory, and short-term visuospatial memory.
Neuropsychological effects of 2-week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea: a randomized placebo-controlled study.
  • W. LimW. Bardwell J. Dimsdale
  • Psychology, Medicine
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • 2007
TLDR
It is suggested that Digit Vigilance-Time might be the most sensitive neuropsychological test for measuring the effects of the treatments of CPAP or oxygen-supplementation treatment, as compared with placebo-CPAP.
Executive Dysfunction and Learning Effect after Continuous Positive Airway Pressure Treatment in Patients with Obstructive Sleep Apnea Syndrome
TLDR
Even long-term CPAP treatment does not seem to improveOSAS patients’ mental set-shifting performance or their visuospatial organizational skills, and OSAS patients have impaired learning effect in executive tests.
Cognitive Dysfunctions in Patients With Severe Obstructive Sleep Apnea Syndrome: Neuropsychological Test and Event-Related Potential Study
TLDR
Findings suggest that severe OSAS patients may have deficits in attention and short-term memory, and abnormal auditory P300.
Executive Dysfunction in Patients with Obstructive Sleep Apnea Syndrome
TLDR
OSAS patients have lower set-shifting and analysis/synthesis performance than healthy controls, and according to the normative data, most patients in the present study had normal performance, but there were also a few patients with more serious deficits.
Cognition in Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS): Current Clinical Knowledge and the Impact of Treatment
TLDR
A review of the literature on OSAS and cognition, including studies that have investigated the impact of CPAP and stimulant medication on cognitive performance in patients with OSAS, finds no consistent effect ofCPAP use on Cognitive performance was evident.
Effects of short-term CPAP withdrawal on neurobehavioral performance in patients with obstructive sleep apnea.
TLDR
Despite recurrence of sleep-disordered breathing with increased sleepiness and impaired vigilance, most neurobehavioral variables were unaffected by CPAP withdrawal, and resumed CPAP treatment had immediate benefits on sleep consolidation and subjective sleepiness.
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References

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Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatment.
TLDR
Short-term memory impairment was persistent in OSAS patients despite CPAP treatment for 4-6 months, and the eventual pathogenic role played by sleep fragmentation and nocturnal hypoxemia, which are related to the occurrence of apneic and hypopneic events, is discussed.
Neuropsychological Effects of One-Week Continuous Positive Airway Pressure Treatment in Patients With Obstructive Sleep Apnea: A Placebo-Controlled Study
TLDR
Although results suggest overall cognitive improvement due to CPAP, no beneficial effects in any specific cognitive domain were found and future studies of neuropsychological effects of CPAP treatment should include a placebo CPAP control group.
Cognitive function in patients with sleep apnea after acute nocturnal nasal continuous positive airway pressure (CPAP) treatment: sleepiness and hypoxemia effects.
TLDR
Subgroup analyses indicted that while vigilance impairment can account for some of the decreased test performance seen in sleep apnea (auditory verbal learning) the effects of severe nocturnal hypoxemia appear to affect other function (sustained attention in repetitive arithmetic calculations) that were not easily modified by treatment.
Neuropsychological function in obstructive sleep apnea syndrome (OSAS) compared to chronic obstructive pulmonary disease (COPD).
Forty-nine men, 25 with obstructive sleep apnea syndrome (OSAS) and 24 with chronic obstructive pulmonary disease (COPD), were evaluated with a standard 8-hour nocturnal polysomnogram, multiple sleep
Persistent neuropsychological deficits and vigilance impairment in sleep apnea syndrome after treatment with continuous positive airways pressure (CPAP).
The obstructive sleep apnea syndrome is characterized by nocturnal sleep disturbance, excessive daytime sleepiness and neuropsychological deficits in the areas of memory, attention, and executive
A Test for the Determination of Sustained Attention in Patients with Obstructive Sleep Apnea Syndrome
TLDR
The attention test can be helpful for the measurement of daytime sleepiness, and CPAP therapy can improve test performance.
Auditory event-related potentials and brain dysfunction in sleep apnea.
Frontal lobe-related cognitive functions in patients with sleep apnea syndrome before and after treatment.
TLDR
Ten patients with SAS were evaluated with various focused frontal lobe-related tests in comparison with ten matched normal controls, found to have normalized most of their cognitive executive and learning disabilities, except for all the short-term memory tests which remained unchanged.
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