Cognitive dysfunction and dementia in Parkinson disease

@article{Caballol2007CognitiveDA,
  title={Cognitive dysfunction and dementia in Parkinson disease},
  author={N{\'u}ria Caballol and Maria Jose Marti and Eduardo Tolosa},
  journal={Movement Disorders},
  year={2007},
  volume={22}
}
Impairment in different cognitive domains such as executive functions, language, memory, and visuospatial skills occurs frequently in Parkinson disease (PD) even in the early stages of the disease. Although frank dementia (Parkinson disease dementia, PDD) is less frequent, risk for developing dementia is two to six times greater than the prevalence rate in general population and it increases in relation to disease duration. Clinically, dementia in PD is characterized by uninsidious onset and… 
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References

SHOWING 1-10 OF 97 REFERENCES
Cognitive dysfunction and dementia in Parkinson’s disease
TLDR
Dementia in PD is typically characterized by a progressive dysexecutive syndrome with attentional deficits and fluctuating cognition, often accompanied by psychotic symptoms, thought to be the result of a combination of both subcortical and cortical changes.
What causes mental dysfunction in Parkinson's disease?
  • M. Emre
  • Psychology, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2003
TLDR
Recent evidence suggests that LB‐type degeneration in limbic structures and cerebral cortex, with consequent synaptic and cell loss, is the main pathological state associated with dementia in PD.
Cognitive impairment in early, untreated Parkinson's disease and its relationship to motor disability.
TLDR
The results indicate dissociation of cognition and motor control in early PD which suggests that cognitive dysfunction is largely independent of frontostriatal dopamine deficiency underlying motor disability, and the pathogenesis of the cognitive deficits shown here appears to involve extrastiatal dopamine systems or non-dopaminergic pathology.
Dementia associated with Parkinson's disease
  • M. Emre
  • Psychology, Biology
    The Lancet Neurology
  • 2003
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
TLDR
In Parkinson's but not Alzheimer's disease the decrease in neocortical (particularly temporal) choline acetyltransferase correlated with the number of neurons in the nucleus of Meynert suggesting that primary degeneration of these cholinergic neurons may be related, directly or indirectly, to declining cognitive function in Parkinson's disease.
Cognitive Predictors of Dementia in Parkinson’s Disease: A Community-Based, 4-Year Longitudinal Study
TLDR
It was concluded that poor performance on a test sensitive to executive dysfunction predicted later development of dementia in PD patients, and this finding may have important clinical implications as a marker of subsequentDevelopment of dementia.
Memory and executive function impairment predict dementia in Parkinson's disease
  • G. Levy, D. Jacobs, K. Marder
  • Psychology, Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 2002
TLDR
It is indicated that impairment in verbal memory and executive function are associated with the development of dementia in patients with PD.
Cognitive and behavioral dysfunction in Parkinson’s disease: neurochemical and clinicopathological contributions
TLDR
Evidence that associates nonmotor dysfunctions with neurochemical and clinicopathological correlates of PD is highlighted.
Neuropsychological characteristics of preclinical dementia in Parkinson's disease
TLDR
Results suggest that poor performance on tests of verbal fluency may represent a distinct characteristic of the preclinical phase of dementia in Parkinson's disease.
Neuropsychological Profile of Patients with Parkinson’s Disease without Dementia
TLDR
The neuropsychological profile of PD patients without dementia was compared with a control group consisting of 38 healthy elderly subjects, and subjects with mild cognitive impairment were older, had a later onset of the disease, and more severe motor symptoms than cognitively intact subjects.
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